Hotels in Upstate South Carolina

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Tonight
Apr 8 - Apr 9
Tomorrow
Apr 9 - Apr 10
This weekend
Apr 11 - Apr 13
Next weekend
Apr 18 - Apr 20

Where to stay in Upstate South Carolina?

The Shepherd Hotel Downtown Clemson
Superior Room, 2 Queen Beds | In-room safe, blackout drapes, soundproofing, iron/ironing board

The Shepherd Hotel Downtown Clemson

4.0 star property
9.8 out of 10, Exceptional, (531)
The price is $199
includes taxes & fees
$179 per night
May 4 - May 5
The Shepherd Hotel Downtown Clemson
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Great weekend hotel deals in Upstate South Carolina, SC

Showing deals for:Apr 18 - Apr 20

Image gallery for The Station by Compo Hotels

Trailside Wedge Cottage | Terrace/patio
VIP Access

The Station by Compo Hotels

4.0 star property
Travelers Rest
10/10Exceptional (5 reviews)
9% off
Price is $318
per night
$783 total
includes taxes & fees
The Station by Compo Hotels

Top neighborhoods in Upstate South Carolina

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Green Avenue

The Green Avenue neighborhood offers attractions such as Falls Park on the Reedy and Greenville Zoo.

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Green Avenue

Top landmarks in Upstate South Carolina

Clemson University

Clemson University

If you'd like to get a taste of Clemson student life, check out Clemson University, located 0.5 mi (0.9 km) from central Clemson.

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Clemson University

Learn more about Upstate South Carolina

Upstate South Carolina is well-known for its university life and sports, featuring attractions such as Discovery Island Water Park and Frankie's Fun Park. This family-friendly city has something for everyone including its live music, restaurants, and sights like Conestee Nature Preserve and Heritage Park.

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Greenville - Spartanburg showing a sunset, tranquil scenes and mountains
Photo by South Carolina Department of Parks, Recreation & Tourism
Open Photo by South Carolina Department of Parks, Recreation & Tourism

Frequently asked questions

What accommodations do travelers like in Upstate South Carolina?
Pettigru Place Bed & Breakfast, The Inn at Patrick Square and Residence Inn by Marriott Anderson Clemson are all properties that our guests really like.
Can I book refundable accommodations in Upstate South Carolina?
If you’re looking for the flexibility to change your plans to Upstate South Carolina, most accommodations provide refundable* rates you can book. You can see these properties by searching our site and using the “fully refundable” filter to narrow the results down.
Which Upstate South Carolina hotels do our guests like for their central location?
Our guests love these properties for their convenient location: Best Western Plus Greenville I-385 Inn & Suites, La Quinta Inn & Suites by Wyndham Greenville Haywood and Hilton Greenville.
Where should I consider staying in Upstate South Carolina if I'm looking for a reasonably priced accommodation?
A few inexpensive options worth considering are Best Western Plus Greenville I-385 Inn & Suites, La Quinta Inn & Suites by Wyndham Greenville Haywood and Comfort Inn Greenville - Haywood Mall. You may want to browse more choices on our site, including 30 motels.
Where can I stay in Upstate South Carolina if I want a vacation rental instead of a hotel?
If you want to find a good alternative to a hotel, browse our selection of 1070 vacation homes. In addition, there are 113 apartments and 89 condos.
Why should I book my Upstate South Carolina hotel through Hotels.com?
There are lots of reasons to book your Upstate South Carolina trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.