Business Hotels in Tenderloin

Free cancellation options if plans change
Unlock travel rewards with One Key
Save more with Member Prices

Check prices for these dates

Tonight
Apr 29 - Apr 30
Tomorrow
Apr 30 - May 1
This weekend
May 2 - May 4
Next weekend
May 9 - May 11

Business Hotels in Tenderloin

Hotel Spero, Vignette Collection by IHG
Exterior

Hotel Spero, Vignette Collection by IHG

4.0 star property
8.8 out of 10, Excellent, (1214)
The price is $160
includes taxes & fees
$136 per night
May 3 - May 4
Hotel Spero, Vignette Collection by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top neighborhoods in Tenderloin

Get a lay of the land and find the perfect place to stay
Downtown San Francisco which includes street scenes and a city

Downtown San Francisco

Serving as San Francisco's central business district, this area boasts Northern California's two tallest buildings, the Salesforce Tower and Transamerica Pyramid. Explore shopping malls like the Embarcadero Center and enjoy parks such as Sue Biermann Park, all easily accessible via Muni bus and rail lines.

See properties in Downtown San Francisco
Downtown San Francisco

Top landmarks in Tenderloin

Oracle Park featuring a bay or harbor and street scenes as well as a small group of people

Oracle Park

Why not catch an event at Oracle Park, a major stadium in Downtown San Francisco. Hotels.com travelers also like the museums, art galleries, and monuments in the area. If you think Oracle Park is cool, you also might like Chase Center and Kezar Stadium, both located nearby.

See properties in Oracle Park
Oracle Park

Frequently asked questions

What are the best business hotels in Tenderloin?
Power through your work projects at Hotel Drisco. This is one of the most popular business hotels in Tenderloin or nearby according to guest reviews. Take advantage of a 24-hour front desk and concierge services here.
What are the cheapest business hotels in Tenderloin?
Holiday Inn Express San Francisco Union Square, an IHG Hotel is a smart pick if you’re looking to save on your work trip. This property features a 24-hour front desk and a free breakfast. Book a cheap Tenderloin business hotel from $102 and keep expenses low and productivity high.
What is the best time to stay in a business hotel in Tenderloin?
If you prefer to visit when crowds are smaller, book your work trip for February. You could snag some amazing deals on business hotels in Tenderloin around then. The warmest weather is in September, with temperatures ranging from 59ºF (15ºC) to 77ºF (25ºC). It’s typically coolest in December, averaging between 48ºF (9ºC) and 57ºF (14ºC).
What business hotels in Tenderloin have a pool?
Make the poolside your office at Mansion on Sutter. You’ll find plenty to love about this Tenderloin business hotel besides its pool, including pillow top mattresses and hypo-allergenic bedding.
What are the best 5-star business hotels in Tenderloin?
Hotel Drisco is a 5-star Tenderloin business hotel that pairs indulgent comforts with corporate conveniences. Everything you need is right here, including complimentary use of a nearby fitness center and designer toiletries.
Are there any business hotels in Tenderloin with parking?
Keep your plans moving smoothly by staying at Omni San Francisco Hotel. Along with parking, you’ll have access to a bar and limousine services. Take your pick of 4,472 Tenderloin business hotels with parking that are perfect for professionals on the move.