Hotels in Santee

your current months are January, 2025 and February, 2025.
January 2025
February 2025
Free cancellation options if plans change
Unlock travel rewards with One Key
Save more with Member Prices

Where to stay in Santee?

Lewis and Clark Resort
32-inch LCD TV with digital channels, TV

Lewis and Clark Resort

2.5 star property
8.6 out of 10, Excellent, (190)
The price is $110
includes taxes & fees
$105 per night
Jan 12 - Jan 13
Lewis and Clark Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top landmarks in Santee

Niobrara showing a river or creek and boating as well as a small group of people

Niobrara State Park

Get friendly with the flora and fauna and spend the day at Niobrara State Park located 2.2 mi (3.5 km) from central Niobrara.

See properties in Niobrara State Park
Niobrara State Park

Learn more about Santee

The region around Santee is home to attractions such as Lewis and Clark Lake and Niobrara State Park.

See all hotels in Santee

Frequently asked questions

What hotels do travelers like in Santee?
Guests like Overlooks Lewis & Clark Lake/Missouri River Basin-3 Hours Northwest of Omaha.
Can I book refundable hotels in Santee?
If you want the flexibility to change your plans to Santee, most hotels provide refundable* rates you can book. You can find these properties by searching our site and using the “fully refundable” filter to narrow down the results.
What will the weather in Santee be like during my visit?
The warmest months in Santee are usually July and August with an average temp of 72°F. January and February are the chilliest months when the average temp is 26°F. The rainiest months are June and May.
Why should I book my Santee accommodation with Hotels.com?
There are lots of reasons to book your Santee trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.