Photo by Jeff White

Hotels in Adrian

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Where to stay in Adrian?

Route 66 Inn & Suites by OYO Vega Tx
Exterior

Route 66 Inn & Suites by OYO Vega Tx

2.5 star property
7.6 out of 10, Good, (318)
$62 nightly
The price is $70
May 27 - May 28
Total includes taxes and fees
Route 66 Inn & Suites by OYO Vega Tx
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Adrian

The region around Adrian is home to attractions such as Midway Point of Route 66 and Magnolia Gas Station.

See all hotels in Adrian
Adrian is just off Interstate 40. It is also the midpoint of the historic Route 66. From here it is 1139 miles East to Chicago and 1139 miles West to Los Angeles. There is also Midpoint Cafe, a 50's style diner with a great burger and fries. However, if you stop you have to ask about their "Ugly Pie."
Photo by Jeff White
Open Photo by Jeff White
A tranquil hotel pool encircled by beautiful arches, enhancing the ambiance for leisure and relaxation.

Summer Getaway Sale

Save 25% or more on select hotels, and earn 50% more rewards on all properties. Book by May 26 and travel by Sep 30, 2025. See terms*
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Frequently asked questions

Can I book refundable hotels in Adrian?
If you want the flexibility to change your travel plans to Adrian, most hotels provide refundable* rates you can book. You can find these accommodations by searching our site and using the “fully refundable” filter to narrow down the results.
What will the weather in Adrian be like during my trip?
The warmest months in Adrian are usually July and August with an average temp of 78°F. January and December are the chilliest months when the average temp is 43°F. The rainiest months are May and October.
Why should I book my Adrian hotel through Hotels.com?
There are plenty of reasons to book your Adrian travel with us: our free cancellations on selected hotels* gives you the flexibility you’re looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Terms and conditions

*Book by 5/26/2025 11:59 pm in hotel property local time. Stay between 4/17/2025-9/30/2025. Member Prices are available to Hotels.com® app users and One Key members. Limited availability, blackout periods may apply.

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