Hotels in Carlisle

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Check prices for these dates

Tonight
May 22 - May 23
Tomorrow
May 23 - May 24
This weekend
May 23 - May 25
Next weekend
May 30 - Jun 1

Where to stay in Carlisle?

Sleep Inn & Suites Pleasant Hill - Des Moines
Indoor pool

Sleep Inn & Suites Pleasant Hill - Des Moines

2.5 star property
8.0 out of 10, Very Good, (807)
$80 nightly
The price is $90
May 29 - May 30
Total includes taxes and fees
Sleep Inn & Suites Pleasant Hill - Des Moines
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top landmarks in Carlisle

MercyOne Carlisle Family Medicine

Though MercyOne Carlisle Family Medicine might be what brings you to town, perhaps you'll have a chance to explore more of Carlisle while you are here.

See properties in MercyOne Carlisle Family Medicine
MercyOne Carlisle Family Medicine

Learn more about Carlisle

The region around Carlisle is home to attractions such as Sleepy Hollow Sports Park and Blank Park Zoo.

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A tranquil hotel pool encircled by beautiful arches, enhancing the ambiance for leisure and relaxation.

Summer Getaway Sale

Save 25% or more on select hotels, and earn 50% more rewards on all properties. Book by May 26 and travel by Sep 30, 2025. See terms*
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Frequently asked questions

What hotels do travelers recommend in Carlisle?
Guests like Hotel Fort Des Moines, Curio Collection by Hilton, Days Inn & Suites by Wyndham Des Moines Airport and Surety Hotel.
Can I book refundable accommodations in Carlisle?
If you need the flexibility to change your plans to Carlisle, most hotels provide refundable* rates you can book. You can find these properties by searching our site and using the “fully refundable” filter to narrow the results down.
Where can I stay with my pet in Carlisle?
Your furry friend can stay with you at this pet-friendly hotel: 250+ Acre Private Hunting/Fishing Lodge - 5 minutes to city.
Where can I stay if I'm traveling to Carlisle with my family?
Your kids are welcome at 250+ Acre Private Hunting/Fishing Lodge - 5 minutes to city.
What will the weather in Carlisle be like during my visit?
The warmest months in Carlisle are usually July and August with an average temp of 72°F. January and February are the chilliest months when the average temp is 29°F. The rainiest months are May and June.
Why should I book my Carlisle hotel through Hotels.com?
There are lots of reasons to book your Carlisle trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Terms and conditions

*Book by 5/26/2025 11:59 pm in hotel property local time. Stay between 4/17/2025-9/30/2025. Member Prices are available to Hotels.com® app users and One Key members. Limited availability, blackout periods may apply.

OneKeyCash is not redeemable for cash and can only be used on Hotels.com®, Expedia®, and Vrbo®.

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